Oxidative stress in cases of chronic fluoride intoxication     

Vinita Ailani  R. C. Gupta  Sunil Kumar Gupta  Kapil Gupta 《Indian journal of clinical biochemistry : IJCB》2009,24(4):426-429

This study was conducted to find out the level of oxidative stress and effect of supplementation of vitamin C, D and Calcium on levels of SOD, serum and urinary fluoride in children residing in endemic fluorosis area. For this the fluoride belt of Jaipur district was selected. The parameters selected were Super oxide dismutase, serum fluoride and urinary fluoride. The study was conducted on one hundred children, selected from four areas (25 from each area) consuming water containing 1.2, 2.4, 5.6 and 13.6 mg/l of fluoride. Drinking water fluoride, serum and urinary fluoride were measured by Ion selective electrode method. Serum SOD by Xanthine oxidase method using kit of Ransod (kit cat. No. SD125). The post treatment values showed a significant reduction in serum fluoride and SOD. Urinary fluoride levels increased significantly in post treatment stage. The results revealed a normal SOD levels in all groups but an increasing trend was observed with increasing fluoride concentration. Treatment with Calcium, Vitamin D and Vitamin C showed a significant reduction in serum fluoride and SOD and increase in urinary fluoride. A high positive correlation between pretreatment and post treatment group was observed in serum fluoride, SOD and urinary fluoride (P < 0.05). The study indicated an increasing oxidative stress in cases of fluorosis with increasing drinking water fluoride concentration. Treatment with Calcium, Vitamin D and Vitamin C resulted a significant reduction in serum fluoride and SOD and increase in urinary fluoride.  相似文献   

Clinicopathological spectrum of non-alcoholic fatty liver disease among patients in Kerala     

Subir Kumar Das  Sukhes Mukherjee  Gaurav Pandey  V. Balakrishnan  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(2):155-158

Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis are entities that are becoming more and more interesting to the medical community in general. A total of 93 Non-alcoholic fatty liver disease patients (64 male and 29 female) within the age range between 28 to 63 years were studied. All of them showed elevated alanine aminotransferase level (104.07 ± 56.04). Aspartate aminotransferase level (58.13 ± 31.96) was elevated more than its normal level in 82% cases and AST to ALT ratio was found 0.59 ± 0.26. Predisposing factors were diabetes mellitus (37%), obesity (13%) and hyperlipidemia (41%). In addition, 32% of the subjects were overweight.18% of the patients had elevated serum bilirubin. Our findings recommend a lower cutoff value than suggested by the World Health Organization for overweight and obesity among this racial-ethnic group.  相似文献   

Get educators to absorb the power of HRD in molding quality education     

Raduan Che Rose  Naresh Kumar 《Performance Improvement》2006,45(9):32-36

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A test strip for the estimation of urea in serum     

Hemant Kumar  Ashok Kumar  Poonam Kumari  N. B. Tulsani 《Indian journal of clinical biochemistry : IJCB》2000,15(2):124-127

We have developed a biostrip for determination of urea in serum. The test strip is based on enzymatic assay where urease has been immobilized on the chromatographic paper along with chromogen, phenol red. The chromogen is easily soluble in water and does not require other components for the color change. Serum urea reacts with urease and water to liberate ammonia and carbon dioxide. The liberated ammonia changes the pH of the reaction medium, which is monitored by the chromogen phenol red. A single step working reagent strip has been developed and the reaction is completed within 50 seconds at room temperature. With this test strip urea concentration is measured in serum as low as 0.15 g/L. The speed and convenience of determining urea in serum by this strip instantly makes it well suited for individuals, physicians and emergency centres.  相似文献   

Managing uncertainty in the real world     

Satish Kumar 《Resonance》1999,4(4):45-55

In Part 1 of this article we understood the idea of a fuzzy set. We also reviewed simple operations such as fuzzy set intersection, union, and complementation, and related these to geometry. In Part 2, we extend the idea of fuzzy sets to explain how we may develop systems that reason with fuzzy sets using fuzzy logic. The idea of extending fuzzy logic to fuzzy engineering and fuzzy function approximation is explored with a working example. It is hoped that readers will be provided with enough motivation to appreciate the use of fuzzy set theory for real world applications.  相似文献   

Lotka's law and institutional productivity   总被引：1，自引：0，他引：1  

Suresh Kumar  Praveen Sharma  K. C. Garg 《Information processing & management》1998,34(6):775-783

The present study aims at determining the applicability of Lotka's law, negative binomial distribution and lognormal distribution for institutional productivity, in the same way as it is to authors and their productivity in the field of engineering sciences and the patents filed by industrial firms in laser S&T. The study indicates that non of the three distributions are applicable for institutional productivity in engineering sciences. However, Lotka's law holds good for full as well as truncated set of data for the patents filed by industrial firms.  相似文献   

Hyperinsulinemia and Hypoadiponectinemia are Associated with Increased Risk for Occurrence of Ovarian Cancer in Non-diabetic Women of North Indian Population     

Rohit Kumar Gupta  Sagar Jayantilal Dholariya  Smita Kaushik  S. K. Gupta  Reva Tripathi  Shyam Lata Jain 《Indian journal of clinical biochemistry : IJCB》2021,36(2):221

Ovarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditions and Group 3: fifty ages matched healthy controls with no evidence of any benign or malignant ovarian pathology as ruled out by clinical examination and relevant investigations. Cytohistopathologically confirmed and newly diagnosed cases of EOC and benign ovarian cancer were included in this study. The median value of fasting serum insulin was significantly high (15.0 µlU/ml, P = 0.02) and adiponectin were significantly low (5.1 µg/ml, P < 0.001) in ovarian cancer patients compared to benign ovarian tumors and healthy controls group. A significant increase risk of ovarian cancer was found in high tertile (≥ 18.7 µlU/ml) of serum insulin level (OR = 2.7; 95% CI = 1.00–6.67, P = 0.04) and lower tertile (≤ 5.45 µg/ml) of adiponectin level (OR = 3.2; 95% CI = 1.10–9.71, P = 0.03). High serum insulin level and low adiponectin levels were significantly associated with increased risk for development of ovarian cancer.  相似文献   

Mohandas Karamchand Gandhi     

Krishna Kumar 《Prospects》1993,23(3-4):507-517

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Theorema Aureum — 1     

Shivam Kumar 《Resonance》2007,12(9):25-39

Are there perfect squares which on division by 7 leave remainder 3? Are there perfect squares which on division by 3 leave remainder 7? (A “remainder of 7” on division by 3 is the same as a remainder of 1.) The answers: ‘NO’ and ‘YES’, respectively. These facts are stated by number theorists as follows: 3 is a quadratic non-residue modulo 7; 7 is a quadratic residue modulo 3. The notion of quadratic residue is far reaching, and the key theorem here is the Law of Quadratic Reciprocity, first stated by Euler in 1783, but without proof, and first proved by Gauss, in 1796. The theorem is easy to state but is mysterious, as it reveals a connection between two questions that appear unconnected. Let p, q be distinct odd primes; then the questions are: “Is p a quadratic residue modulo q?” and “Is q a quadratic residue modulo p?” Gauss had a high regard for this result and called it Theorema Aureum, the Golden Theorem. Though it has been proved in many different ways, it retains its mystery. In this two part article we give three proofs of the theorem. The first one, described in this part, is based on group theory.  相似文献   

Assessment of glycemic potential of<Emphasis Type="Italic">Musa paradisiaca</Emphasis> stem juice     

Santosh Kumar Singh  Achyut Narayan Kesari  Prashant Kumar Rai  Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2007,22(2):48-52

The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats. The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucose levels within 1h during glucose tolerance test (GTT) and a rise of 16% after 4 h in fasting blood glucose levels of severe diabetic cases. These results were unexpected and important to report as other species of Musa like Musa sapientum has been reported for its hypoglycemic effect.  相似文献